What does the Stupp Protocol involve?

The Stupp Protocol is the global standard of care for newly diagnosed glioblastoma (GBM). It combines radiotherapy (RT) delivered over six weeks with daily oral temozolomide (TMZ) chemotherapy. After this initial phase, patients receive six cycles of adjuvant TMZ alone. The entire regimen is typically administered on an outpatient basis, with regular monitoring of blood counts and clinical status to manage side effects.