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What is Growth Hormone Therapy?

Recombinant human growth hormone (rhGH) daily injections restore growth in children with GH deficiency, Turner syndrome, SHOX deficiency, and other conditions. Long-term treatment from childhood to near-final height achieves substantial height gains (average +7-10 cm over untreated).

Why China?

• Cost (annual): $4,500-$9,500 vs. $20,000-$60,000 in the US
• Domestic rhGH: GeneScience Jintropin (long market experience) + new weekly formulations
• Weekly options: Jintrolong PEGylated hGH (1 injection/week) — unique to China
• Expert care: PUMC and Shanghai Children's have 5,000+ GH therapy patients

Who is a candidate?

• GH deficiency (peak GH <10 ng/mL on 2 stimulation tests)
• Idiopathic short stature (height <-2.25 SDS)
• Turner syndrome
• Chronic kidney disease with growth failure
• Prader-Willi, SHOX deficiency, Noonan

Outcomes

Height velocity in year 1: 2-3x baseline. Near-final height gain: 7-12cm for GHD, 5-8cm for ISS/Turner. Early treatment initiation (<age 6) maximizes benefit.